For the past two seasons Bolton have come away victorious from Old Trafford and they will be hoping they can start the season on a positive note against Sir Alex Ferguson's team.
Bolton could hand debuts to new signings Stelios Giannakopoulos and Kevin Davies whilst last season's loan stars Florent Laville and Ivan Campo have signed permanently and will probably start the game against the Champions.
Another new signing Mario Jardel is set to miss the game as the formalities for the strikers move from Sporting Lisbon will not be completed until the beginning of next week.
United begin life without David Beckham and they could be faced with a defensive crisis with Wes Brown, Phil Neville, Gary Neville and Mickael Silvestre all struggling with injuries.
American goalkeeper Tim Howard may be given a debut whilst other new signings Klebersen, Christiano Ronaldo, David Bellion and Eric Djemba-Djemba may also feature at some point during the game.
Bolton's recent record against the Red Devils is good, the Wanderers haven't been beaten at Old Trafford since September 1995 and United have only won once in the last six league meetings home or away between the two sides which was a 4-0 win at the Reebok Stadium in January 2002
PLAYED FOR BOTH TEAMS
JOHN BALL
PETER BARNES
PETER BEARDSLEY
WYN DAVIES
TONY DUNNE
ALAN GOWLING
BRIAN KIDD
HARRY MCSHANE
WILLIE MORGAN
JOHN O'KANE
PAUL WHEATCROFT
BILL WRIGGLESWORTH