Bolton midfielder Mark Davies looks set to miss the short trip to Old Trafford after injuring his ankle during the FA Cup win over Birmingham.
Full back Gretar Steinsson is expected to be fit despite suffering from a bug in midweek.
Man Utd
Suspended: Scholes (two matches)
Doubtful: Evans (ankle), Owen (groin), Park (hamstring)
Injured: Anderson, Hargreaves & Lindegaard (all knee), Ferdinand (calf), Fletcher (illness), O'Shea & Rafael (both hamstring), Vidic (calf)
Bolton
Doubtful: M Davies (ankle), Steinsson (virus)
Injured: S Davis, Knight & J O'Brien (all knee), Gardner (thigh), Ricketts (Achilles), Samuel (calf/fitness)
MATCH PREVIEW
The Treble is still on, but Manchester United will be hoping to avoid an altogether less desirable hat-trick when Bolton come to town on Saturday.
Every time we enter the field we think we have a chance of winning games and we will certainly need all that come Saturday against, for me, the champions elect and a team that as everybody knows, are purely outstanding on every front
Bolton boss Owen Coyle
Sir Alex Ferguson's men have booked their place in the last eight of the Champions League and the FA Cup semi-finals in the past week, but they return to league action looking to reassert their authority in the title race after successive defeats.
United's cause will not be helped by a number of key absentees, including the manager himself, who will watch the game from the stands following a five-match Football Association ban for comments made about referee Martin Atkinson.
Ferguson will not be short of company - a deepening injury crisis could deprive United of 10 outfield players, while Paul Scholes starts his own suspension after picking up his 10th booking of the season.
Bolton have won just one of their last 16 Premier League games against United, but they arrive in Manchester in excellent form, with six wins in their last eight matches and a place in the FA Cup semi-finals secured.
MATCH FACTS
Head-to-head
• Man Utd have won 10 of their last 12 meetings against Bolton.
• Wanderers have lost their last seven visits to Old Trafford since a 1-0 win back in September 2002.
• Wayne Rooney has scored six goals in eight Premier League games for Manchester United against Bolton.
Man Utd
• United have lost three of their last five league matches, including their last two.
• They have not lost three Premier League games in a row since December 2001.
• Wayne Rooney has scored five goals in his last six Premier League appearances, and is two short of 100 Premier League goals for United.
• Javier Hernandez has scored 10 goals from just 14 shots on target in the Premier League this season.
Bolton
• Bolton have lost only one of their last five Premier League matches.
• Only five of the last 10 Premier League penalties taken against Jussi Jaaskelainen have resulted in a goal (four saved, one missed).
• They are winless in their last seven Premier League away matches since a 3-2 victory at Wolves on 13 November.
LEADING GOALSCORERS
Man Utd
Berbatov: 20 goals (19 league); Hernandez: 16 goals (10 league)
Bolton
Elmander: 11 goals (9 league); K Davies: 9 goals (7 league); Sturridge: 8 goals* (4 league)
* Sturridge scored 4 goals (0 league) for Chelsea
MATCH OFFICIALS
Referee: Andre Marriner
Assistant referees: Mike Cairns & Jake Collin
Fourth official: Eddie Ilderton
LAST LEAGUE MATCH LINE-UPS
Man Utd (L1-3 v Liverpool, a): Van der Sar; Rafael (O'Shea 76), Smalling, Brown, Evra, Nani (Hernandez 45), Carrick, Scholes (Fletcher 83), Giggs, Berbatov, Rooney. Subs not used: Kuszczak, Fabio, Obertan, Gibson.
Bolton (W3-2 v Aston Villa, h): Jaaskelainen; Steinsson, Wheater, Cahill, Robinson, Elmander (Klasnic 67), Holden, Muamba (M Davies 60), Petrov (Lee 60), K Davies, Sturridge. Subs not used: Bogdan, Taylor, Moreno, Alonso.
Source: BBC Sport
Source: BBC Sport