First half strikes from Middlesbrough's Graeme Owen and Tom Craddock gave the visitors at strong advantage going in at half time as Bolton were left routed to the bottom of the table after yet another Reserve defeat.
Just after half time, Bradley Hill pulled it back to 2-1 but only five minutes later Boro regained their two goal cushion thanks to Adam Johnson.
TEAM:
Ashton, Powell, Stott, Whitehead, Fojut, Hill, Sissons (Cassidy 83), Roddy (Mountford 45), Smith, Sinclair (Wolfe 64), Luisi.
SUBS NOT USED:
Kazimerczak, Charlesworth.