Included in the team are Radhi Jaidi, Ivan Campo, Anthony Barness, Henrik Pedersen, Ricardo Vaz-Te, Khalilou Fadiga and Julio Cesar who returns to action for the first time since breaking his foot in December.
Irish midfielder Joey O'Brien is also amongst the starting eleven having successfully completed a three month loan spell with League One side Sheffield Wednesday earlier this month.
Kevin Poole and Florent Laville make up the experienced faces within the Wanderers team as Neil McDonald's side look for their first win since defeating Leeds United at Belle Vue a month ago.
Former Wanderers loanee Jon Otsemobor is included in the Liverpool squad which makes the short journey to Lancashire. Fellow defender Zak Whitebread, midfielders Richie Partridge and David Mannix have all previously tasted action in the first team at Anfield.
Goalkeeper Paul Harrison is back in the Reds fold having completed a short spell on loan at Championship side Leeds United.
Earlier on this season two goals from the afforementioned Vaz-Te gave the Trotters the honours in the reverse fixture at the Racecourse Ground in Wrexham.
BOLTON RESERVES: Kevin Poole, Anthony Barness, Julio Cesar, Radhi Jaidi, Florent Laville, Ivan Campo, Joey O'Brien, Khalilou Fadiga, Bedi Buval, Henrik Pedersen, Ricardo Vaz-Te
SUBS: Dale Whitehead, Chris Howarth, Jason Talbot, Jaroslaw Fojut
LIVERPOOL RESERVES: Paul Harrison, Jon Otsemobor, James Smith, Danny O'Donnell, Zak Whitbread, David Mannix, Ryan Wilkie, Danny Guthrie, Phil Townley, Karl Noon, Richie Partridge
SUBS: Paul Barratt, Patrice Luzi, Danny Smith, Adam Hitchin, Adam Hammil