Newcastle had ended the Wanderers unbeaten run which stretched back to early September, so coach Neil McDonald will be hoping that the defeat against the Magpies will not have had too much of an effect on his players.
Ivan Campo will get a chance to build up his fitness in this game whilst there is also places for experienced pair Kevin Poole and Julio Cesar.
A year ago when Bolton faced Blackburn in this reserve team fixture the two sides contested a 1-1 draw at Christie Park, Morecambe. Mario Jardel netted for the Trotters in what was to be the first of two local derbies that week.
Full team news to appear later.
BOLTON RESERVES: Kevin Poole, Danny Livesey, Jason Talbot, Charlie Comyn-Platt, Julio Cesar, Ivan Campo, Joey O'Brien, Craig Knowles, Ricardo Vaz-Te, Ricky Shakes, Reda Kribib
SUBS: Dale Whitehead, Rhys Powell, Karl Luisi, Bradley Hill, Luke Magill
ROVERS RESERVES: David Yelldell, Gavin Peers, Alan Morgan, Neil Danns, John Fitzgerald, Alex Bruce, Ciaran Donnelly, Gary Harkin, Jemal Johnson, Matt Derbyshire, Joel Byrom
SUBS: Steve Drench, Eddie Nolan, Luke Jones, Ralph Welch, Keith Barker, Gary Stopforth